Copyright 2020 Leaf Group Ltd. / Leaf Group Media, All Rights Reserved. Before using or dispensing any product, read and carefully observe the label directions. Talk to the vet about any precautions to take while applying Profender. 4. In a laboratory study, cats artificially infected with adult heartworms and treated with PROFENDER Topical Solution had fewer worms recovered than the placebo control group. Copyright © 2020 Animalytix LLC. However, the licking and grooming can cause a cat to ingest the drug to the point that it may experience physical side effects. In most cases, a single dose may effectively control the infection [3]. The formulation and dosage schedule is designed to provide a minimum of 1.36 mg/lb (3 mg/kg) emodepside and 5.45 mg/lb (12 mg/kg) praziquantel based on body weight. The most serious side effects occur if Profender is given orally instead of topically. Reproduction in whole or in part without permission is prohibited. In other cases, Profender can cause a cat to become lethargic. The physical side effects of Profender include hair loss and excessive salivation. Most cats hate to be held firmly and forced to ingest a medication. He has been writing since 1987 and has written for NPR, AP, Boeing, Ford New Holland, Microsoft, RAHCO International, Umax Data Systems and other manufacturers in Taiwan. Praziquantel is an isoquinoline cestocide. Adverse reactions reported by the cat owners included licking/excessive grooming in 18 cats (3.0%), scratching treatment site in 15 cats (2.5%), salivation in 10 cats (1.7%), lethargy in 10 cats (1.7%), alopecia in 8 cats (1.3%), agitation/nervousness in 7 cats (1.2%), vomiting in 6 cats (1.0%), diarrhea in 3 cats (0.5%), eye irritation in 3 cats (0.5%), respiratory irritation in 1 cat (0.2%) and shaking/tremors in 1 cat (0.2%). Studies performed in rats and rabbits suggest that emodepside may interfere with fetal development in those species. Profender (emodepside/praziquantel) Topical Solution. Regulations for product use are established by country. * Cats over 17.6 lbs should be treated with the appropriate combination of tubes. Pregnant women, or women who may become pregnant, should avoid direct contact with, or wear disposable gloves when applying, this product. Oral ingestion or exposure should be avoided. Twist the cap to break the seal and then remove cap from the tube. Use with caution in heartworm positive cats. Profender is protected by the following U.S. (See Table below.). For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at In a field study, PROFENDER Topical Solution was used in cats receiving other frequently used products including: analgesics, anti-fungals, non-steroidal anti-inflammatories, anthelmintics, antimicrobials, flea and tick products, sedatives, anesthetics, cardiac medications, anxiolytics, hormonal treatments, steroids, otic and ophthalmic preparations, and vaccines. There the two active ingredients interact with the systems of the susceptible parasites [1]. Reactions such as facial, tongue and hand swelling have been reported in humans in rare instances. The physical side effects of Profender include hair loss and excessive salivation. Safe use of this product has not been evaluated in cats less than 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy or in lactating queens. Profender is a broad-spectrum deworming medication used for controlling and treating parasitic infections [1, 2]. The physical side effects of Profender include hair loss and excessive salivation. Avoid contact with the application area while it is wet and wash hands thoroughly with soap and warm water after handling. PROFENDER Topical Solution may be irritating to skin and eyes. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. One cat treated with a vehicle placebo (formulation minus the active ingredients) showed salivation, gagging, lethargy and a swollen tongue. Treatment at the base of the head will minimize the opportunity for ingestion while grooming. 5. Less than 8 weeks old or weigh less than 2.2lbs, Hypersensitive to its primary ingredients, Profender® Topical Solution (emodepside/praziquantel) –, Profender (emodepside/praziquantel) Topical Solution –, Diagnosis and Management Of Lungworm Infections in Cats –, Emodepside/Praziquantel (Profender®) for Dogs and Cats –, Profender Topical Parasiticide for Small Cats (Canada) –. Pet owners deal with scratches. If re-infection occurs, the product can be re-applied after 30 days. Follow the dosage directions given by your vet. Oral exposure can cause salivation and vomiting. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. He speaks fluent Mandarin Chinese, English and reads Spanish. All rights reserved. It may also be used to treat multi-parasitic infections in cats [1]. General Safety Study in Kittens: PROFENDER Topical Solution was topically applied at 0X (vehicle control), 1X, 3X and 5X the maximum dose to 48 healthy 8-week-old kittens every two weeks for six doses. He studied creative writing at Mankato State University in Minnesota. 7. Also prevent your cat from licking itself for an hour after applying the medication, and quarante it from other pets so they do not get exposed to it [3, 6]. While holding the tube in an upright position, remove the cap from the tube. A third 5X kitten experienced tremors the day after dosing. Although he grew up in Latin America, Mr. Ma is a writer based in Denver. The recommended minimum dose is 1.36 mg/lb (3 mg/kg) emodepside + 5.45 mg/lb (12 mg/kg) praziquantel as a single topical dose. Your email address will not be published. Listings by active ingredient may represent more than one brand name. Profender should not be used in young animals (cats under 8 weeks of age or weighing less than 0.5 kg, or puppies under 12 weeks of age or weighing less than 1 kg). A few behavioural side effects can occur after Profender is applied. To ensure the entire contents of the tube are administered, place the tip of the tube on the skin and squeeze the entire contents directly onto the skin. Emodepside, a semi-synthetic molecule, is a cyclic depsipeptide. cats image by Zbigniew Nowak from Patents: 5 514 773 and other patents pending. Another cat exhibited tremors and lethargy. PROFENDER [1.98% emodepside/7.94% praziquantel] Topical Solution is a clear yellow ready-to-use solution packaged in single unit dosing applicator tubes for topical (dermal) treatment of cats 8 weeks of age and older and weighing at least 2.2 lbs (1 kg). Bayer, the Bayer Cross and Profender are registered trademarks of Bayer. Temporary effects like a damp appearance or stiffening of the hair, and a powdery residue may be seen at the site of application [9]. Plus, if the cat didn't take all the medication, you remain unsure that enough medicine was swallowed to kill off the worms. Adverse reactions reported by the cat owners included licking/ excessive grooming in 18 cats (3.0%), scratching treatment site in 15 cats (2.5%), salivation in 10 cats (1.7%), lethargy in 10 cats (1.7%), alopecia in 8 cats (1.3%), agitation/nervousness in 7 cats (1.2%), vomiting in 6 cats (1.0%), diarrhea in 3 cats (0.5%), eye irritation in 3 cats (0.5%), respiratory irritation in 1 cat (0.2%) and shaking/tremors in 1 … However, these occur in rare cases and usually go away without further treatment [1]. Clinical signs included salivation (one 1X and three 5X cats), labored breathing (all groups) and lethargy (one 5X cat). In rare cases, the drug can trigger vomiting and diarrhoea. In some cases, you may notice eye and respiratory irritation. Do not apply to broken skin or if hair coat is wet. Reinfections are usually rare, but if it occurs, the dewormer may be reapplied after consulting a vet [3]. All of the physical side effects are a direct result of the cat ingesting the drug, a label contraindication. The physical side effects of Profender include hair loss and excessive salivation. For a complete listing of adverse reactions for Profender Topical Solution reported to the CVM see: Available for Android and iOS devices. 6. However, in some cases, a cat who licks the application site may suffer more severe side effects than a cat who does not. Safety Study in Heartworm Positive Cats: Cats artificially infected with adult heartworms harvested from dogs were treated topically with PROFENDER Topical Solution at 0X, 1X or 5X the recommended dose once a month for three treatments. Required fields are marked *. The Material Safety Data Sheet (MSDS) provides additional occupational safety information. Avoid its use on broken skin or wet coat [3], and make sure not to get the medicine in your cat’s eyes or mouth [6]. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To prevent accidental ingestion of the product, children should not come in contact with the application site for twenty-four (24) hours while the product is being absorbed.

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